Primary Identifier | MGI:108025 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 19087 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including beta-2 adrenergic receptor binding activity; cAMP binding activity; and enzyme binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm. Part of cAMP-dependent protein kinase complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and leg. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). PHENOTYPE: Homozygous null mice are viable and appear healthy. They have normal growth and no deficits in locomotor activity, muscle strength, or exploratory behavior. [provided by MGI curators] |