| Primary Identifier | MGI:108443 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12796 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable lipopolysaccharide binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and innate immune response. Acts upstream of or within defense response to Gram-negative bacterium and killing by host of symbiont cells. Located in specific granule. Is expressed in several structures, including gut; heart; hemolymphoid system; lung; and testis. Orthologous to human CAMP (cathelicidin antimicrobial peptide). PHENOTYPE: Mice homozygous for a knock-out allele are more susceptible to necrotic skin infection caused by Group A Streptococcus and urinary tract infection caused by uropathogenic E. coli and F. solani-induced keratitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
