| Primary Identifier | MGI:1918177 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 235626 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone H3K36 methyltransferase activity. Involved in endodermal cell differentiation and stem cell differentiation. Acts upstream of or within several processes, including chordate embryonic development; peptidyl-lysine trimethylation; and tube morphogenesis. Located in chromosome and nucleus. Is expressed in cerebral cortex; early embryo; and inner cell mass. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; clear cell renal cell carcinoma; gastrointestinal system cancer (multiple); lung disease (multiple); and malignant mesothelioma (multiple). Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
