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Protein Coding Gene : Nradd neurotrophin receptor associated death domain

Primary Identifier  MGI:1914419 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  67169
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable several functions, including coreceptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in Rho protein signal transduction. Located in lamellipodium; membrane; and nuclear envelope lumen. Is expressed in dorsal root ganglion; medulla oblongata; retina layer; and spinal cord. Orthologous to human NRADDP (neurotrophin receptor associated death domain, pseudogene).
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no significant change in the total number of dorsal root ganglion (DRG) sensory neurons, despite an increased proportion of DRG sensory neurons expressing p75NTR. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2610311B09 gene,
  • MGI:2143359,
  • BB104149,
  • NRDD,
  • expressed sequence BB104149,
  • PLAIDD,
  • 2610311B09Rik,
  • neurotrophin receptor associated death domain,
  • Nradd

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Canonical gene --> Transcripts in specific strains.

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