| Primary Identifier | MGI:98658 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 21667 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including Wnt-protein binding activity; coreceptor activity; and nodal binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; brain; extraembryonic component; gonad; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including CRIPTO (cripto, EGF-CFC family member). PHENOTYPE: Mice homozygous for disruptions in this gene display abnormalities in rostral-caudal axis formation, embryonic development and heart development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
