| Primary Identifier | MGI:1352447 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12780 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables toxin transmembrane transporter activity. Involved in heme catabolic process. Acts upstream of or within several processes, including mercury ion transport; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in apical plasma membrane and intercellular canaliculus. Is active in cell surface; plasma membrane; and vesicle. Is expressed in foregut; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). PHENOTYPE: Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urine bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
