Primary Identifier | MGI:107824 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 12773 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables C-C chemokine receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; interneuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; limb; liver and biliary system; and reproductive system. Orthologous to human CCR4 (C-C motif chemokine receptor 4). PHENOTYPE: Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration. [provided by MGI curators] |