Primary Identifier | MGI:101833 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 13712 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including mediator complex binding activity; transcription regulator activator activity; and transcription regulator inhibitor activity. Acts upstream of or within several processes, including liver development; lung development; and positive regulation of DNA-templated transcription. Predicted to be located in several cellular components, including axon terminus; mitochondrial membrane; and neuronal cell body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ELK1 (ETS transcription factor ELK1). PHENOTYPE: Targeted inactivation of this gene causes no apparent phenotype. Hemizygous males carrying the HygTk gene of a null allele are sterile, likely due to aberrant expression of the Tk gene in the testis; phenotypic correction is obtained with a second null allele that does not contain the Tk gene. [provided by MGI curators] |