| Primary Identifier | MGI:98932 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 22352 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables RNA binding activity. A structural constituent of cytoskeleton and structural constituent of eye lens. Involved in several processes, including intermediate filament organization; positive regulation of axon extension; and positive regulation of protein localization. Acts upstream of or within several processes, including astrocyte differentiation; cellular response to type II interferon; and lens fiber cell development. Located in several cellular components, including cell leading edge; intermediate filament; and phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Used to study cataract 30. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Sjogren's syndrome; cataract 30; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human VIM (vimentin). PHENOTYPE: Homozygous null mutants exhibit impaired performance in motor coordination tests; cerebellum shows underdeveloped/abnormal Bergman glia and stunted, poorly branched Purkinje cells. Mutants are unable to survive experimental 75% reduction of kidney mass. Homozygosity for a phosphorylation-blocking allele leads to small eyes and premature aging of the eyes (cataracts). [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
