| Primary Identifier | MGI:95810 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 53623 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term synaptic potentiation. Located in postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and organ of Corti. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). PHENOTYPE: Male mice hemizygous for one allele display reduced fertility and enhanced long term potentiation. Male mice hemizygous for a second allele display decreased thermal nociception, resistance to drug induced seizures and a decreased startle reflex; and homozygous female mice have decreased body weight [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
