| Primary Identifier | MGI:1098583 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 20843 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Acts upstream of or within stem cell population maintenance. Located in chromatin. Is expressed in several structures, including genitourinary system; integumental system; limb; liver; and nervous system. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). PHENOTYPE: Mice hemizygous for a conditionally allele activated in embryos exhibit death at E10.5 with growth retardation and cardiac defects associated with reduced cell proliferation. Knockdown of expression of this gene results in lineage skewing of hematopoietic stem cells and myeloproliferative disorders in aged mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
