| Primary Identifier | MGI:1353624 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 30878 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable apelin receptor binding activity; hormone activity; and identical protein binding activity. Involved in apelin receptor signaling pathway; coronary vasculature development; and positive regulation of G protein-coupled receptor internalization. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; liver and biliary system; and trunk. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human APLN (apelin). PHENOTYPE: Mice homozygous for one null allele display narrower small vessels and a reduction in the density of vessels in some capillary beds. Mice homozygous or hemizygous for a second null allele display impaired cardiac function with age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
