Primary Identifier | MGI:2443910 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 320376 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1). PHENOTYPE: Mice homozygous for a null allele exhibit male infertility with oligozoospermia and abnormal sperm mitochondrial sheath morphology with large vacuoles. [provided by MGI curators] |