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Protein Coding Gene : Mcf2 mcf.2 transforming sequence
Primary Identifier  MGI:96932 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  109904
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and dendrite development. Predicted to be active in cytoplasm. Is expressed in femur; fibula; and tibia. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence).
PHENOTYPE: Homozygous and hemizygous null mice are viable, fertile and behaviorally normal, exhibit normal gonad and brain development and neuronal migration, but show a significant reduction of basal dendritic length in distinct subpopulations of cortical pyramidal neurons. [provided by MGI curators]
  • synonyms:
  • MGI:2444059,
  • MGD-MRK-12134,
  • Mcf-2,
  • B230117G22Rik,
  • RIKEN cDNA B230117G22 gene,
  • Mcf2,
  • MGD-MRK-12135,
  • Dbl,
  • mcf.2 transforming sequence
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