Primary Identifier | MGI:107683 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 18846 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables semaphorin receptor activity. Involved in nervous system development; positive regulation of cytoskeleton organization; and semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including hippocampus development; negative regulation of axon extension involved in axon guidance; and neuron development. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Orthologous to human PLXNA3 (plexin A3). PHENOTYPE: Mice homozygous for disruptions in this gene possess misdirected axons in the hippocampus. They are, otherwise, indistinguishable from wild-type mice. [provided by MGI curators] |