Primary Identifier | MGI:105941 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 17524 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor binding activity. Involved in regulation of neutrophil chemotaxis. Located in cortical cytoskeleton and membrane. Is expressed in several structures, including alimentary system; bone; retina; trigeminal ganglion; and umbilical vein. Orthologous to human MPP1 (MAGUK p55 scaffold protein 1). PHENOTYPE: Mice homozygous for a knock-out allele display defects in neutrophil polarity and chemotaxis and produce small litters of pups. [provided by MGI curators] |