Primary Identifier | MGI:1277207 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 12766 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of angiogenesis; and regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3). PHENOTYPE: Mice homozygous or hemizygous for disruptions in this gene display immune system abnormalities. Hemizygous male mice exhibit elevated serum glucose levels. [provided by MGI curators] |