Primary Identifier | MGI:98974 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 213742 |
Mgi Type | lncRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ribonucleoprotein complex binding activity. Acts upstream of or within inactivation of paternal X chromosome by genomic imprinting; random inactivation of X chromosome; and spongiotrophoblast differentiation. Located in X chromosome and nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; neural retina; and spleen. Orthologous to human XIST (X inactive specific transcript). PHENOTYPE: Xist function in X-inactivation is disrupted in females carrying a null mutation. Depending on maternal or paternal derivation of the mutation, females survive or die in early embryogenesis. In either case, X-inactivation is non-random and abnormal. [provided by MGI curators] |