| Primary Identifier | MGI:2148050 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 245555 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in negative regulation of cell adhesion and negative regulation of neuron migration. Predicted to be located in cytosol; midbody; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural tube mantle layer; sensory organ; skeleton; and tarsus. Used to study autism spectrum disorder and non-syndromic X-linked intellectual disability 98. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 98. Orthologous to human NEXMIF (neurite extension and migration factor). PHENOTYPE: Male mice hemizygous for a knock-out allele show seizures, autism-like behaviors including reduced sociability, repetitive self-grooming, hyperactivity, decreased vocalization and deficits in spatial and fear memory, as well as a reduction in dendritic spine density and synaptic transmission. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
