| Primary Identifier | MGI:1931627 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 80903 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of endothelial cell chemotaxis to fibroblast growth factor. Predicted to act upstream of or within positive regulation of brown fat cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including branchial arch; heart; inner ear; nose; and tongue. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16). PHENOTYPE: Males hemizygous for one null allele show reduced fetal cardiomyocyte proliferation and postnatal cardiomyocyte numbers. Males hemizygous for another null allele die in midgestation with craniofacial and heart defects including cardiac hemorrhage, chamber dilation, thin walls and poor trabeculation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
