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Protein Coding Gene : Tspan6 tetraspanin 6
Primary Identifier  MGI:1926264 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  56496
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of cytoplasmic pattern recognition receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in 1st branchial arch; jaw; and pancreas epithelium. Orthologous to human TSPAN6 (tetraspanin 6).
PHENOTYPE: Female mice homozygous for a null allele exhibit enhanced basal synaptic transmission and reduced long term potentiation (LTP) while hemizygous males show abnormal motor learning but no deficits in locomotor behavior or hippocampus-dependent memory tasks. [provided by MGI curators]
  • synonyms:
  • MGI:1924400,
  • tetraspanin 6,
  • 6720473L21Rik,
  • Tspan6,
  • expressed sequence AI316786,
  • RIKEN cDNA 6720473L21 gene,
  • Tm4sf6,
  • transmembrane 4 superfamily member 6,
  • AI316786,
  • MGI:2147866
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