| Primary Identifier | MGI:1343054 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 108062 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in cleavage body. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2). PHENOTYPE: Embryonic stem cells (ESCs) hemizygous for a gene trap allele show a specific loss of differentiation potential toward the endodermal lineage and a severe defect in cardiomyocyte differentiation. Mutant ESCs differentiated into embryoid bodies fail to cavitate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
