| Primary Identifier | MGI:1096388 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 13984 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within labyrinthine layer blood vessel development; labyrinthine layer morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hindlimb phalanx; and viscerocranium. Orthologous to human ESX1 (ESX homeobox 1). PHENOTYPE: Hemizygous males and heterozygous females who inherit a null targeted mutation from their mothers exhibit defects in the labyrinthine layer of the placenta resulting in impaired vascularization and reduced birth weights. Adult mutant weights are normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
