| Primary Identifier | MGI:1914139 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 66889 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cytokine production. Located in Golgi apparatus; endoplasmic reticulum; and late endosome. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human RNF128 (ring finger protein 128). PHENOTYPE: Mice homozygous for a null allele dsiplay defects in naive, helper and anergic T cell states affecting survival, proliferation and cytokine secretion. Homozygotes for another null allele show impaired T cell tolerance and regulatory T cell function and increased susceptibility to autoimmune disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
