| Primary Identifier | MGI:1276110 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 12738 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and paracellular tight junction channel activity. Involved in several processes, including calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; innate immune response in mucosa; and regulation of intestinal absorption. Located in bicellular tight junction. Is expressed in alimentary system; brain; genitourinary system; and submandibular gland primordium. Orthologous to human CLDN2 (claudin 2). PHENOTYPE: Nullizygous females show altered Na+ and water reabsorption in the kidney proximal tubules. Males hemizygous for a null allele show increased transcellular Na+ reabsorption in the thick ascending limb, higher renal oxygen consumption, medullary hypoxia, and susceptibility to ischemic renal injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
