| Primary Identifier | MGI:1338009 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 16370 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4). PHENOTYPE: Homozygotes for a targeted null mutation exhibit a 10% reduction in male adult size, slightly impaired oral glucose tolerance, and decreased reproductive ability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
