| Primary Identifier | MGI:1098622 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 51869 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Involved in regulation of DNA metabolic process; regulation of gene expression; and telomere maintenance. Acts upstream of or within cellular response to leukemia inhibitory factor and stem cell population maintenance. Located in chromosome and pronucleus. Is active in chromosome, telomeric repeat region. Is expressed in several structures, including 4-8 cell stage conceptus; blastocyst-stage conceptus; early embryo; reproductive system; and urinary system. Orthologous to human RIF1 (replication timing regulatory factor 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
