| Primary Identifier | MGI:96281 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 15560 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; phospholipase C-activating serotonin receptor signaling pathway; and regulation of corticotropin-releasing hormone secretion. Acts upstream of or within positive regulation of calcium-mediated signaling and positive regulation of fat cell differentiation. Predicted to be located in external side of plasma membrane. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Used to study Prader-Willi syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C). PHENOTYPE: Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
