| Primary Identifier | MGI:95674 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 14526 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables receptor ligand activity. Involved in several processes, including cellular response to glucagon stimulus; positive regulation of calcium ion import; and positive regulation of cell communication. Acts upstream of or within negative regulation of execution phase of apoptosis; positive regulation of gluconeogenesis; and regulation of insulin secretion. Located in cytoplasm and extracellular region. Is active in plasma membrane. Is expressed in brain; gut; liver; and urogenital ridge. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon). PHENOTYPE: Mice homozygous for a knock-out allele exhibit islet alpha cell hyperplasia and increased body weight. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
