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Protein Coding Gene : Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

Primary Identifier  MGI:103287 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  22184
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2).
PHENOTYPE: Mice inheriting a null allele maternally and a paternal null allele for Zrsr1 fail to develop beyond the 2 cell stage, with very few reaching morula stage and none implanting. [provided by MGI curators]
  • synonyms:
  • MGI:3036362,
  • 5031411E02Rik,
  • MGD-MRK-24168,
  • Zrsr2,
  • A230052C13Rik,
  • expressed sequence C77286,
  • U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1, related sequence 2,
  • U2af1-rs2,
  • RIKEN cDNA 5031411E02 gene,
  • MGI:2148049,
  • 35kDa,
  • C77286,
  • MGI:2445088,
  • RIKEN cDNA A230052C13 gene,
  • zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2

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