Primary Identifier | MGI:103287 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 22184 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). PHENOTYPE: Mice inheriting a null allele maternally and a paternal null allele for Zrsr1 fail to develop beyond the 2 cell stage, with very few reaching morula stage and none implanting. [provided by MGI curators] |