| Primary Identifier | MGI:88121 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 11998 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable neuropeptide hormone activity; protein kinase activity; and vasopressin receptor binding activity. Predicted to be involved in several processes, including grooming behavior; maternal aggressive behavior; and maternal behavior. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and renal water absorption. Predicted to be located in dendrite. Predicted to be active in extracellular region and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; integumental system; nervous system; and sensory organ. Used to study neurohypophyseal diabetes insipidus. Human ortholog(s) of this gene implicated in diabetes insipidus; neurohypophyseal diabetes insipidus; opioid abuse; and schizophrenia. Orthologous to human AVP (arginine vasopressin). PHENOTYPE: Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
