| Primary Identifier | MGI:1338758 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 11538 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in neuron differentiation; positive regulation of canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of neuron apoptotic process. Located in extracellular region. Is expressed in central nervous system; future brain; placenta; and retina. Used to study Helsmoortel-Van Der Aa Syndrome. Human ortholog(s) of this gene implicated in Helsmoortel-Van Der Aa Syndrome. Orthologous to human ADNP (activity dependent neuroprotector homeobox). PHENOTYPE: Developmental defects including the failure of the cranial neural tube to close lead to embryonic death between E8.5 and E9. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
