| Primary Identifier | MGI:1919397 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 72147 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription cis-regulatory region binding activity; and transcription coregulator activity. Involved in negative regulation of transcription by RNA polymerase II; regulatory T cell differentiation; and tolerance induction in gut-associated lymphoid tissue. Acts upstream of or within regulation of leukocyte differentiation. Located in chromatin. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; brown fat; central nervous system; and gonad. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). PHENOTYPE: Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
