| Primary Identifier | MGI:88496 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 12918 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables corticotropin-releasing hormone activity. Involved in general adaptation syndrome; positive regulation of corticotropin secretion; and social behavior. Acts upstream of or within several processes, including adrenal gland development; glucocorticoid biosynthetic process; and locomotory exploration behavior. Located in neuronal cell body. Is active in extracellular region. Is expressed in several structures, including central nervous system; extraembryonic component; lung; placenta; and thymus. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone). PHENOTYPE: Homozygous null mice have abnormal adrenal gland morphology, decreased corticosterone levels and abnormal corticosteroid responses to stress. Homozygous litters born from homozygous females display neonatal lethality, impaired lung maturation and delayedcornified and granular layer development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
