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Protein Coding Gene : Mfn1 mitofusin 1
Primary Identifier  MGI:1914664 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  67414
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0)

Predicted to enable GTPase activity and identical protein binding activity. Involved in positive regulation of mitochondrial membrane potential. Acts upstream of or within mitochondrial fusion. Located in mitochondrion. Is expressed in several structures, including 2-cell stage conceptus; blastocyst-stage conceptus; placenta; retina; and tibialis anterior. Orthologous to human MFN1 (mitofusin 1).
PHENOTYPE: Mice homozygous for disruptions in this gene die in mid gestation. Structural and functional abnormalities of mitochondria are reported. [provided by MGI curators]
  • synonyms:
  • Mfn1,
  • D3Ertd265e,
  • MGI:1916768,
  • 2310002F04Rik,
  • DNA segment, Chr 3, ERATO Doi 265, expressed,
  • 6330416C07Rik,
  • HR2,
  • RIKEN cDNA 6330416C07 gene,
  • MGI:1098715,
  • mitofusin 1,
  • RIKEN cDNA 2310002F04 gene
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Features --> Cross References

Genome

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1 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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