| Primary Identifier | MGI:108418 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 18167 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables peptide YY receptor activity. Involved in negative regulation of eating behavior; negative regulation of neuronal action potential; and negative regulation of peptide secretion. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is active in 9+0 non-motile cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; cocaine dependence; nicotine dependence; and obesity (multiple). Orthologous to human NPY2R (neuropeptide Y receptor Y2). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
