| Primary Identifier | MGI:1334433 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 107650 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Is active in Golgi apparatus. Is expressed in allantois; amnion; neural ectoderm; trophectoderm; and vertebral axis musculature. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 87. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). PHENOTYPE: Mice homzygous for a conditional allele activated in Schwann cells exhibit limb grasping, hindlimb spasticity, abnormal gait, decreased nerve conduction velocity, abnormal node of Ranvier morphology, and abnormal Schwann cell morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
