Primary Identifier | MGI:2442939 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 212933 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including adaptive thermogenesis; amide catabolic process; and energy homeostasis. Located in extracellular space. Is expressed in embryo; embryo endoderm; and notochord. Orthologous to human PM20D1 (peptidase M20 domain containing 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit variety of metabolic and pain phenotypes, including insulin resistance, altered body temperature in cold, and antinociceptive behaviors. [provided by MGI curators] |