| Primary Identifier | MGI:1336173 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 108079 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; protein localization to lipid droplet; and regulation of autophagy. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; peptidyl-serine phosphorylation; and response to muscle activity. Located in several cellular components, including cytoplasmic stress granule; dendrite; and neuronal cell body. Is active in cytosol and late endosome. Is expressed in several structures, including brain; genitourinary system; gut; lung; and spinal cord. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). PHENOTYPE: Homozygous null mice are hyperglycemic, hypoinsulinemic, and show glucose intolerance and insulin resistance. Homozygosity for a phosphorylation-blockingblocking (p.T172A) or KO allele leads to Alzheimer������s disease-like phenotypes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
