| Primary Identifier | MGI:98957 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 22417 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables frizzled binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of testosterone biosynthetic process; and positive regulation of cellular component biogenesis. Acts upstream of or within several processes, including Wnt signaling pathway; adenohypophysis development; and morphogenesis of an epithelium. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). PHENOTYPE: Homozygous mutants exhibit impaired development of the kidney, pituitary gland, and female reproductive system. Mutants die within 24 hours of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
