| Primary Identifier | MGI:104652 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12345 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables beta-tubulin binding activity. Contributes to actin filament binding activity. Acts upstream of or within several processes, including activation of protein kinase C activity; negative regulation of protein polymerization; and plasma membrane bounded cell projection organization. Located in several cellular components, including Z disc; intercalated disc; and sperm head-tail coupling apparatus. Part of F-actin capping protein complex. Is active in Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Is expressed in brain; foregut; heart; and skeletal muscle. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). PHENOTYPE: Mice homozygous for a conditional allele activated in the ear exhibit increased ABR threshold, absent DPOE, reduced vestibular function, head shaking and abnormal stereocilia length and width in the cochlea and utricle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
