| Primary Identifier | MGI:1330832 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 17175 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including calcium-dependent protein binding activity; complement component C4b binding activity; and serine-type endopeptidase activity. Acts upstream of or within complement activation, lectin pathway. Predicted to be located in Golgi apparatus. Predicted to be part of serine-type endopeptidase complex. Predicted to be active in extracellular region and symbiont cell surface. Is expressed in brain and liver. Orthologous to human MASP2 (MBL associated serine protease 2). PHENOTYPE: Homozygous disruption of the exon encoding the small mannose-binding lectin (MBL)-associated protein results in a defective lectin-mediated complement pathway with a 20% reduction in the ability of serum components to cleave C3 and C4 in the presence of mannose. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
