| Primary Identifier | MGI:104512 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 22163 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables tumor necrosis factor receptor activity. Involved in negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and positive regulation of B cell proliferation. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF receptor superfamily member 4). PHENOTYPE: Homozygote null mice have defects in T cell response to antigen including proliferation, production of cytokines, and generation of memory T cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
