| Primary Identifier | MGI:97568 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18669 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including ATP binding activity; ATPase-coupled intramembrane lipid carrier activity; and transmembrane transporter activity. Acts upstream of or within several processes, including adult heart development; aldosterone secretion; and neural tissue regeneration. Located in intercellular canaliculus. Is expressed in several structures, including 2-cell stage conceptus; central nervous system; early embryo; oocyte; and small intestine. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are hypersensitive to effects of drugs transported by phosphoglycoproteins. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
