| Primary Identifier | MGI:2444248 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231659 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein serine/threonine kinase activator activity. Involved in GCN2-mediated signaling and cellular response to amino acid starvation. Located in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; lung; and trophectoderm. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). PHENOTYPE: Homozygous inactivation of this gene results in decreased embryo size, embryonic growth retardation, and complete lethality during organogenesis. Mice homozygous for a knock-out allele exhibit embryo turning defects, abnormal head shape, abnormally vascularized yolk sacs, and placentation defects, along with severe heart defects and an open cranial neural tube. Mice homozygous for a deletion of the RWD binding domain show mild embryonic growth retardation, perinatal lethality due to respiratory failure, and cell cycle and proliferation defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
