| Primary Identifier | MGI:1354737 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 30841 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3K36 demethylase activity. Involved in several processes, including brain development; embryonic morphogenesis; and negative regulation of neuron apoptotic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and positive regulation of stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of PcG protein complex and SCF ubiquitin ligase complex. Is expressed in genitourinary system; lung; and telencephalon. Orthologous to human KDM2B (lysine demethylase 2B). PHENOTYPE: Mice homozygous for a targeted allele that does not express the long form protein exhibit exencephaly, fetal and postnatal lethality, coloboma, curly tail, oligozoospermia, increased apoptosis, and increased neuronal precursor proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
