| Primary Identifier | MGI:1341826 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20445 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). PHENOTYPE: A specific missense mutation affects protein glycosylation in intestinal endothelial cells and leads to thinning of the colon inner mucus layer, increased microbial invasion of colon mucus and more severe DSS-induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
