| Primary Identifier | MGI:1096397 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 20019 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable DNA/RNA hybrid binding activity; chromatin binding activity; and metal ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in negative regulation of protein localization to nucleolus; nucleolar large rRNA transcription by RNA polymerase I; and transcription elongation by RNA polymerase I. Located in chromosome and nucleus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit failure of blastocyst formation, increased cell death, and complete embryonic lethality before implantation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
