| Primary Identifier | MGI:109147 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 18430 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables oxytocin receptor activity. Involved in several processes, including maternal behavior; milk ejection reflex; and positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; brain; exocrine gland; genitourinary system; and gut. Human ortholog(s) of this gene implicated in alcohol dependence; depressive disorder; impulse control disorder; personality disorder; and substance abuse (multiple). Orthologous to human OXTR (oxytocin receptor). PHENOTYPE: Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
