| Primary Identifier | MGI:88022 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 11727 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tRNA-specific ribonuclease activity. Involved in several processes, including defense response to other organism; hematopoietic stem cell proliferation; and post-transcriptional regulation of gene expression. Located in extracellular space; growth cone; and neuronal cell body. Is active in nucleus. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and respiratory system. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). PHENOTYPE: Knock-out mice show increased proliferative capacity of hematopoietic stem/progenitor cells and decreased proliferative capacity of myeloid-restricted progenitor cells and develop leukopenia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
